272291

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2703333..2704573 Replicon chromosome
Accession NZ_CP117818
Organism Legionella pneumophila strain D5916

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag PT257_RS12050 Protein ID WP_161505104.1
Coordinates 2703638..2704573 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag PT257_RS12045 Protein ID WP_161505103.1
Coordinates 2703333..2703641 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT257_RS12010 (PT257_12010) 2698806..2699666 + 861 WP_161505101.1 DUF2608 domain-containing protein -
PT257_RS12015 (PT257_12015) 2700016..2700315 - 300 WP_161505102.1 hypothetical protein -
PT257_RS12020 (PT257_12020) 2700326..2700637 - 312 WP_011947278.1 cupin -
PT257_RS12025 (PT257_12025) 2700628..2700909 - 282 WP_050598290.1 hypothetical protein -
PT257_RS12030 (PT257_12030) 2701085..2701558 + 474 WP_027222478.1 hypothetical protein -
PT257_RS12035 (PT257_12035) 2701748..2702665 + 918 WP_161505105.1 LysR family transcriptional regulator -
PT257_RS12040 (PT257_12040) 2703109..2703336 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
PT257_RS12045 (PT257_12045) 2703333..2703641 + 309 WP_161505103.1 HipA N-terminal domain-containing protein Antitoxin
PT257_RS12050 (PT257_12050) 2703638..2704573 + 936 WP_161505104.1 lpg2370 family Dot/Icm T4SS effector Toxin
PT257_RS12055 (PT257_12055) 2704618..2704782 - 165 WP_202621185.1 hypothetical protein -
PT257_RS12060 (PT257_12060) 2704875..2706020 + 1146 WP_284647222.1 serine kinase -
PT257_RS12065 (PT257_12065) 2706030..2707217 - 1188 WP_284647223.1 fatty acid desaturase -
PT257_RS12070 (PT257_12070) 2707342..2707509 - 168 WP_011214444.1 DUF3309 family protein -
PT257_RS12075 (PT257_12075) 2707621..2707794 + 174 WP_284647224.1 hypothetical protein -
PT257_RS12080 (PT257_12080) 2707887..2708321 + 435 WP_237578533.1 hypothetical protein -
PT257_RS12085 (PT257_12085) 2708362..2709294 - 933 WP_040147818.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35949.81 Da        Isoelectric Point: 9.5553

>T272291 WP_161505104.1 NZ_CP117818:2703638-2704573 [Legionella pneumophila]
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISLSPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQKIIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKQLNFF

Download         Length: 936 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT272291 WP_161505103.1 NZ_CP117818:2703333-2703641 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References