Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 1122977..1123830 | Replicon | chromosome |
| Accession | NZ_CP117818 | ||
| Organism | Legionella pneumophila strain D5916 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | - |
| Locus tag | PT257_RS04975 | Protein ID | WP_042754999.1 |
| Coordinates | 1122977..1123483 (-) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | - |
| Locus tag | PT257_RS04980 | Protein ID | WP_042754998.1 |
| Coordinates | 1123483..1123830 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PT257_RS04945 (PT257_04945) | 1118064..1118873 | - | 810 | WP_042755003.1 | integrase domain-containing protein | - |
| PT257_RS04950 (PT257_04950) | 1119275..1119463 | + | 189 | WP_136629085.1 | hypothetical protein | - |
| PT257_RS04955 (PT257_04955) | 1119477..1121249 | - | 1773 | WP_042755002.1 | ATP-binding protein | - |
| PT257_RS04960 (PT257_04960) | 1121443..1121706 | + | 264 | WP_042755001.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| PT257_RS04965 (PT257_04965) | 1121699..1121951 | + | 253 | Protein_970 | type II toxin-antitoxin system YafQ family toxin | - |
| PT257_RS04970 (PT257_04970) | 1122242..1122601 | + | 360 | WP_042755000.1 | MarR family transcriptional regulator | - |
| PT257_RS04975 (PT257_04975) | 1122977..1123483 | - | 507 | WP_042754999.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| PT257_RS04980 (PT257_04980) | 1123483..1123830 | - | 348 | WP_042754998.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| PT257_RS04985 (PT257_04985) | 1123900..1125150 | - | 1251 | WP_061784227.1 | tyrosine-type recombinase/integrase | - |
| PT257_RS04990 (PT257_04990) | 1125499..1126001 | + | 503 | Protein_975 | transposase | - |
| PT257_RS04995 (PT257_04995) | 1126065..1127233 | + | 1169 | WP_105625152.1 | IS3 family transposase | - |
| PT257_RS05000 (PT257_05000) | 1127525..1128193 | + | 669 | WP_061636258.1 | HAD family phosphatase | - |
| PT257_RS05005 (PT257_05005) | 1128344..1128553 | + | 210 | WP_226997367.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 19527.21 Da Isoelectric Point: 9.5699
>T272289 WP_042754999.1 NZ_CP117818:c1123483-1122977 [Legionella pneumophila]
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS
Download Length: 507 bp
Antitoxin
Download Length: 116 a.a. Molecular weight: 13175.84 Da Isoelectric Point: 4.9405
>AT272289 WP_042754998.1 NZ_CP117818:c1123830-1123483 [Legionella pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR
Download Length: 348 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|