Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 1123928..1124781 | Replicon | chromosome |
| Accession | NZ_CP117817 | ||
| Organism | Legionella pneumophila strain D5573 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | - |
| Locus tag | PT256_RS05255 | Protein ID | WP_042754999.1 |
| Coordinates | 1123928..1124434 (-) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | - |
| Locus tag | PT256_RS05260 | Protein ID | WP_042754998.1 |
| Coordinates | 1124434..1124781 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PT256_RS05225 (PT256_05225) | 1119015..1119824 | - | 810 | WP_042755003.1 | integrase domain-containing protein | - |
| PT256_RS05230 (PT256_05230) | 1120226..1120414 | + | 189 | WP_136629085.1 | hypothetical protein | - |
| PT256_RS05235 (PT256_05235) | 1120428..1122200 | - | 1773 | WP_042755002.1 | ATP-binding protein | - |
| PT256_RS05240 (PT256_05240) | 1122394..1122657 | + | 264 | WP_042755001.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| PT256_RS05245 (PT256_05245) | 1122650..1122902 | + | 253 | Protein_971 | type II toxin-antitoxin system YafQ family toxin | - |
| PT256_RS05250 (PT256_05250) | 1123193..1123552 | + | 360 | WP_042755000.1 | MarR family transcriptional regulator | - |
| PT256_RS05255 (PT256_05255) | 1123928..1124434 | - | 507 | WP_042754999.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| PT256_RS05260 (PT256_05260) | 1124434..1124781 | - | 348 | WP_042754998.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| PT256_RS05265 (PT256_05265) | 1124851..1126101 | - | 1251 | WP_061784227.1 | tyrosine-type recombinase/integrase | - |
| PT256_RS05270 (PT256_05270) | 1126450..1126952 | + | 503 | Protein_976 | transposase | - |
| PT256_RS05275 (PT256_05275) | 1127016..1128184 | + | 1169 | WP_105625152.1 | IS3 family transposase | - |
| PT256_RS05280 (PT256_05280) | 1128476..1129144 | + | 669 | WP_061636258.1 | HAD family phosphatase | - |
| PT256_RS05285 (PT256_05285) | 1129295..1129504 | + | 210 | WP_226997367.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 19527.21 Da Isoelectric Point: 9.5699
>T272287 WP_042754999.1 NZ_CP117817:c1124434-1123928 [Legionella pneumophila]
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS
Download Length: 507 bp
Antitoxin
Download Length: 116 a.a. Molecular weight: 13175.84 Da Isoelectric Point: 4.9405
>AT272287 WP_042754998.1 NZ_CP117817:c1124781-1124434 [Legionella pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR
Download Length: 348 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|