Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 1161348..1162201 | Replicon | chromosome |
| Accession | NZ_CP117814 | ||
| Organism | Legionella pneumophila strain D5241 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | - |
| Locus tag | PT258_RS05165 | Protein ID | WP_042754999.1 |
| Coordinates | 1161348..1161854 (-) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | - |
| Locus tag | PT258_RS05170 | Protein ID | WP_042754998.1 |
| Coordinates | 1161854..1162201 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PT258_RS05135 (PT258_05135) | 1156435..1157244 | - | 810 | WP_042755003.1 | integrase domain-containing protein | - |
| PT258_RS05140 (PT258_05140) | 1157646..1157834 | + | 189 | WP_136629085.1 | hypothetical protein | - |
| PT258_RS05145 (PT258_05145) | 1157848..1159620 | - | 1773 | WP_042755002.1 | ATP-binding protein | - |
| PT258_RS05150 (PT258_05150) | 1159814..1160077 | + | 264 | WP_042755001.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| PT258_RS05155 (PT258_05155) | 1160070..1160322 | + | 253 | Protein_1008 | type II toxin-antitoxin system YafQ family toxin | - |
| PT258_RS05160 (PT258_05160) | 1160613..1160972 | + | 360 | WP_042755000.1 | MarR family transcriptional regulator | - |
| PT258_RS05165 (PT258_05165) | 1161348..1161854 | - | 507 | WP_042754999.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| PT258_RS05170 (PT258_05170) | 1161854..1162201 | - | 348 | WP_042754998.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| PT258_RS05175 (PT258_05175) | 1162271..1163521 | - | 1251 | WP_061784227.1 | tyrosine-type recombinase/integrase | - |
| PT258_RS05180 (PT258_05180) | 1163870..1164372 | + | 503 | Protein_1013 | transposase | - |
| PT258_RS05185 (PT258_05185) | 1164436..1165604 | + | 1169 | WP_105625152.1 | IS3 family transposase | - |
| PT258_RS05190 (PT258_05190) | 1165896..1166564 | + | 669 | WP_061636258.1 | HAD family phosphatase | - |
| PT258_RS05195 (PT258_05195) | 1166715..1166924 | + | 210 | WP_226997367.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 19527.21 Da Isoelectric Point: 9.5699
>T272284 WP_042754999.1 NZ_CP117814:c1161854-1161348 [Legionella pneumophila]
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS
Download Length: 507 bp
Antitoxin
Download Length: 116 a.a. Molecular weight: 13175.84 Da Isoelectric Point: 4.9405
>AT272284 WP_042754998.1 NZ_CP117814:c1162201-1161854 [Legionella pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGHVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR
Download Length: 348 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|