Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3677290..3677950 Replicon chromosome
Accession NZ_CP117782
Organism Burkholderia sp. FERM BP-3421

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Bsp3421_RS32825 Protein ID WP_274001146.1
Coordinates 3677290..3677622 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Bsp3421_RS32830 Protein ID WP_274001148.1
Coordinates 3677615..3677950 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Bsp3421_RS32805 (Bsp3421_006558) 3672560..3672982 + 423 WP_274001142.1 CopD family protein -
Bsp3421_RS32810 (Bsp3421_006559) 3673079..3673936 - 858 WP_274001143.1 MurR/RpiR family transcriptional regulator -
Bsp3421_RS32815 (Bsp3421_006560) 3674231..3676084 + 1854 WP_274001144.1 phosphogluconate dehydratase -
Bsp3421_RS32820 (Bsp3421_006561) 3676102..3676728 + 627 WP_274001145.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
Bsp3421_RS32825 (Bsp3421_006562) 3677290..3677622 + 333 WP_274001146.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Bsp3421_RS32830 (Bsp3421_006563) 3677615..3677950 + 336 WP_274001148.1 helix-turn-helix transcriptional regulator Antitoxin
Bsp3421_RS32835 (Bsp3421_006564) 3678328..3679692 + 1365 WP_274001150.1 gluconate:H+ symporter -
Bsp3421_RS32840 (Bsp3421_006565) 3679706..3680212 + 507 WP_274001152.1 gluconokinase -
Bsp3421_RS32845 (Bsp3421_006566) 3680271..3680936 - 666 WP_274001154.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
Bsp3421_RS32850 (Bsp3421_006567) 3681213..3682676 + 1464 WP_274001156.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-103)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12845.03 Da        Isoelectric Point: 10.0559

>T272268 WP_274001146.1 NZ_CP117782:3677290-3677622 [Burkholderia sp. FERM BP-3421]
MAFDWTIVYYNERVKRDVLAFPVGILADYLRLLDLMQEFGADLRMPYSRAMGNGLFELRPKGREGIGRVFYCTHVGRQVV
VLHAFVKKTQETPPHELRIAQIRLREVRHG

Download         Length: 333 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 11737.31 Da        Isoelectric Point: 9.5971

>AT272268 WP_274001148.1 NZ_CP117782:3677615-3677950 [Burkholderia sp. FERM BP-3421]
MAEEKAGKRVRAAGFNPVPHTADDTARLLAAGGVKEAYDALEDEYTALRAILSARRDAGLTQAQIAERMGTTASAVSRLE
ASLASEKHSPSFATLRKYAAACGKRLVISFA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References