Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1780592..1781197 Replicon chromosome
Accession NZ_CP117781
Organism Burkholderia sp. FERM BP-3421

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag Bsp3421_RS10875 Protein ID WP_273995957.1
Coordinates 1780919..1781197 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Bsp3421_RS10870 Protein ID WP_273995955.1
Coordinates 1780592..1780897 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Bsp3421_RS10855 (Bsp3421_002176) 1776662..1777747 - 1086 WP_273995952.1 ionic transporter y4hA -
Bsp3421_RS10860 (Bsp3421_002177) 1777999..1779588 + 1590 WP_273995953.1 3-hydroxyacyl-CoA dehydrogenase PaaH -
Bsp3421_RS10865 (Bsp3421_002178) 1779662..1780465 + 804 WP_273995954.1 enoyl-CoA hydratase-related protein -
Bsp3421_RS10870 (Bsp3421_002179) 1780592..1780897 - 306 WP_273995955.1 HigA family addiction module antitoxin Antitoxin
Bsp3421_RS10875 (Bsp3421_002180) 1780919..1781197 - 279 WP_273995957.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Bsp3421_RS10880 (Bsp3421_002181) 1781450..1782118 + 669 WP_273995959.1 MarC family protein -
Bsp3421_RS10885 (Bsp3421_002182) 1782134..1783000 - 867 WP_273995960.1 CPBP family glutamic-type intramembrane protease -
Bsp3421_RS10890 (Bsp3421_002183) 1783096..1783884 - 789 WP_273995962.1 DUF3050 domain-containing protein -
Bsp3421_RS10895 (Bsp3421_002184) 1784354..1785055 - 702 WP_273995964.1 fumarylacetoacetate hydrolase family protein -
Bsp3421_RS10900 (Bsp3421_002185) 1785183..1786103 - 921 WP_273995966.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(27-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10514.18 Da        Isoelectric Point: 8.9187

>T272266 WP_273995957.1 NZ_CP117781:c1781197-1780919 [Burkholderia sp. FERM BP-3421]
MIQSFRCRNTAALFAGAPPPAFRAFERVACRKLAMLDAAHALRDLAAPPGNMLEALSGDRRHQYCIRINQRWRLCFEWTE
KGPAQVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11507.33 Da        Isoelectric Point: 6.7275

>AT272266 WP_273995955.1 NZ_CP117781:c1780897-1780592 [Burkholderia sp. FERM BP-3421]
MKTINAMPAIHPGEVLREEFLAPLALSVNALSLALVVPATRLHEIVKERRGITADTAYRLARYFGTTAEFWLNLQIDYDL
KILPTRDEINRKVEPREPHEA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References