Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4117034..4117764 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag PTC84_RS19925 Protein ID WP_023302825.1
Coordinates 4117034..4117348 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTC84_RS19930 Protein ID WP_032620773.1
Coordinates 4117348..4117764 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS19905 (PTC84_19905) 4112700..4113785 + 1086 Protein_3890 cellulase family glycosylhydrolase -
PTC84_RS19910 (PTC84_19910) 4113691..4114875 - 1185 WP_015570118.1 multidrug efflux MFS transporter EmrD -
PTC84_RS19915 (PTC84_19915) 4115051..4115884 - 834 WP_273961602.1 DMT family transporter -
PTC84_RS19920 (PTC84_19920) 4115947..4116393 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
PTC84_RS19925 (PTC84_19925) 4117034..4117348 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
PTC84_RS19930 (PTC84_19930) 4117348..4117764 + 417 WP_032620773.1 helix-turn-helix domain-containing protein Antitoxin
PTC84_RS19935 (PTC84_19935) 4117911..4118009 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
PTC84_RS19940 (PTC84_19940) 4118116..4119804 + 1689 WP_023302827.1 acetolactate synthase large subunit -
PTC84_RS19945 (PTC84_19945) 4119808..4120095 + 288 WP_015570113.1 acetolactate synthase small subunit -
PTC84_RS19950 (PTC84_19950) 4120221..4120814 + 594 WP_003861054.1 transcriptional regulator UhpA -
PTC84_RS19955 (PTC84_19955) 4120811..4122316 + 1506 WP_180242744.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T272249 WP_023302825.1 NZ_CP117750:4117034-4117348 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15249.77 Da        Isoelectric Point: 5.2068

>AT272249 WP_032620773.1 NZ_CP117750:4117348-4117764 [Enterobacter hormaechei]
MIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVGI
AVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FIL2

Antitoxin

Source ID Structure

References