Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2833174..2833849 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag PTC84_RS13740 Protein ID WP_015571638.1
Coordinates 2833174..2833473 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag PTC84_RS13745 Protein ID WP_015571639.1
Coordinates 2833484..2833849 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS13715 (PTC84_13715) 2828371..2828721 - 351 WP_023295279.1 flagellar transcriptional regulator FlhD -
PTC84_RS13720 (PTC84_13720) 2829078..2829806 - 729 WP_251993367.1 RNA polymerase sigma factor FliA -
PTC84_RS13725 (PTC84_13725) 2829976..2831292 - 1317 WP_273961564.1 methyl-accepting chemotaxis protein -
PTC84_RS13730 (PTC84_13730) 2831312..2831743 + 432 Protein_2692 ATP-binding cassette domain-containing protein -
PTC84_RS13735 (PTC84_13735) 2831724..2832923 + 1200 WP_273961565.1 HlyD family efflux transporter periplasmic adaptor subunit -
PTC84_RS13740 (PTC84_13740) 2833174..2833473 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC84_RS13745 (PTC84_13745) 2833484..2833849 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
PTC84_RS13750 (PTC84_13750) 2833876..2835057 - 1182 WP_196277491.1 PLP-dependent aminotransferase family protein -
PTC84_RS13755 (PTC84_13755) 2835078..2835965 - 888 WP_045338869.1 LysR substrate-binding domain-containing protein -
PTC84_RS13760 (PTC84_13760) 2836063..2836665 + 603 WP_017382759.1 short chain dehydrogenase -
PTC84_RS13765 (PTC84_13765) 2836662..2837393 - 732 WP_039269965.1 class I SAM-dependent methyltransferase -
PTC84_RS13770 (PTC84_13770) 2837556..2838713 - 1158 WP_023295456.1 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T272246 WP_015571638.1 NZ_CP117750:2833174-2833473 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT272246 WP_015571639.1 NZ_CP117750:2833484-2833849 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References