Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 453410..454137 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTC84_RS02155 Protein ID WP_045348581.1
Coordinates 453826..454137 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B3V464
Locus tag PTC84_RS02150 Protein ID WP_022650546.1
Coordinates 453410..453829 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS02140 (PTC84_02140) 451240..452361 - 1122 WP_015571201.1 YbdK family carboxylate-amine ligase -
PTC84_RS02145 (PTC84_02145) 452467..453357 + 891 WP_063933147.1 oxidoreductase -
PTC84_RS02150 (PTC84_02150) 453410..453829 - 420 WP_022650546.1 helix-turn-helix domain-containing protein Antitoxin
PTC84_RS02155 (PTC84_02155) 453826..454137 - 312 WP_045348581.1 type II toxin-antitoxin system HigB family toxin Toxin
PTC84_RS02160 (PTC84_02160) 454735..456252 + 1518 WP_165468254.1 hypothetical protein -
PTC84_RS02165 (PTC84_02165) 456624..456926 - 303 WP_165468255.1 hypothetical protein -
PTC84_RS02170 (PTC84_02170) 457171..457773 + 603 WP_023320086.1 site-specific integrase -
PTC84_RS02175 (PTC84_02175) 457910..458578 + 669 WP_023296073.1 epoxyqueuosine reductase QueH -
PTC84_RS02180 (PTC84_02180) 458802..458996 - 195 WP_223825263.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12562.47 Da        Isoelectric Point: 9.9435

>T272239 WP_045348581.1 NZ_CP117750:c454137-453826 [Enterobacter hormaechei]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPLPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHADYDKLMDYYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15447.51 Da        Isoelectric Point: 4.6051

>AT272239 WP_022650546.1 NZ_CP117750:c453829-453410 [Enterobacter hormaechei]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3V464

References