Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5648051..5648646 Replicon chromosome
Accession NZ_CP117749
Organism Pseudomonas aeruginosa strain 2022CK-00828

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PTC91_RS26845 Protein ID WP_003113526.1
Coordinates 5648368..5648646 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTC91_RS26840 Protein ID WP_003133769.1
Coordinates 5648051..5648356 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC91_RS26805 (PTC91_26805) 5643192..5644040 + 849 WP_003095007.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PTC91_RS26815 (PTC91_26815) 5644207..5645148 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PTC91_RS26820 (PTC91_26820) 5645265..5645879 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PTC91_RS26825 (PTC91_26825) 5645921..5646505 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PTC91_RS26830 (PTC91_26830) 5646546..5647646 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PTC91_RS26840 (PTC91_26840) 5648051..5648356 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
PTC91_RS26845 (PTC91_26845) 5648368..5648646 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC91_RS26850 (PTC91_26850) 5648699..5648827 - 129 Protein_5307 integrase -
PTC91_RS26855 (PTC91_26855) 5648975..5651203 + 2229 WP_019485341.1 TonB-dependent receptor -
PTC91_RS26860 (PTC91_26860) 5651273..5651920 - 648 WP_003095021.1 carbonate dehydratase -
PTC91_RS26865 (PTC91_26865) 5651982..5653220 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T272237 WP_003113526.1 NZ_CP117749:c5648646-5648368 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT272237 WP_003133769.1 NZ_CP117749:c5648356-5648051 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References