Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 358435..359081 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag PTC85_RS01645 Protein ID WP_032433636.1
Coordinates 358435..358782 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag PTC85_RS01650 Protein ID WP_019725405.1
Coordinates 358782..359081 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS01635 (354361) 354361..355794 + 1434 WP_032433640.1 glycogen synthase GlgA -
PTC85_RS01640 (355812) 355812..358259 + 2448 WP_032433638.1 glycogen phosphorylase -
PTC85_RS01645 (358435) 358435..358782 + 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC85_RS01650 (358782) 358782..359081 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
PTC85_RS01655 (359144) 359144..360652 - 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
PTC85_RS01660 (360857) 360857..361186 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
PTC85_RS01665 (361237) 361237..362067 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
PTC85_RS01670 (362117) 362117..362875 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T272213 WP_032433636.1 NZ_CP117745:358435-358782 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT272213 WP_019725405.1 NZ_CP117745:358782-359081 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References