Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3629412..3630072 Replicon chromosome
Accession NZ_CP117730
Organism Klebsiella grimontii strain 2022CK-00781

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTC90_RS17300 Protein ID WP_049089248.1
Coordinates 3629719..3630072 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag PTC90_RS17295 Protein ID WP_004132739.1
Coordinates 3629412..3629714 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC90_RS17265 (PTC90_17260) 3624417..3625871 + 1455 WP_024359975.1 AMP nucleosidase -
PTC90_RS17275 (PTC90_17270) 3626900..3628357 - 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
PTC90_RS17285 (PTC90_17280) 3628681..3629014 - 334 Protein_3400 type II toxin-antitoxin system PemK/MazF family toxin -
PTC90_RS17290 (PTC90_17285) 3629015..3629218 - 204 Protein_3401 hypothetical protein -
PTC90_RS17295 (PTC90_17290) 3629412..3629714 - 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
PTC90_RS17300 (PTC90_17295) 3629719..3630072 - 354 WP_049089248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC90_RS17305 (PTC90_17300) 3630456..3631874 - 1419 WP_154926204.1 heavy metal sensor histidine kinase -
PTC90_RS17310 (PTC90_17305) 3631874..3632542 - 669 WP_004132733.1 heavy metal response regulator transcription factor -
PTC90_RS17315 (PTC90_17310) 3632682..3633308 + 627 WP_004132731.1 hypothetical protein -
PTC90_RS17320 (PTC90_17315) 3633323..3633931 + 609 WP_154926207.1 cytochrome b/b6 domain-containing protein -
PTC90_RS17325 (PTC90_17320) 3633921..3634688 + 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13639.64 Da        Isoelectric Point: 9.8874

>T272188 WP_049089248.1 NZ_CP117730:c3630072-3629719 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSDMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT272188 WP_004132739.1 NZ_CP117730:c3629714-3629412 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References