Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15454..15712 Replicon chromosome
Accession NC_017628
Organism Escherichia coli IHE3034

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag ECOK1_RS00085 Protein ID WP_000809168.1
Coordinates 15454..15606 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15655..15712 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOK1_RS00065 10699..11412 - 714 WP_001102393.1 acidic protein MsyB -
ECOK1_RS00070 11438..11842 - 405 WP_000843687.1 DUF2541 family protein -
ECOK1_RS00075 12214..14130 + 1917 WP_000516135.1 molecular chaperone DnaK -
ECOK1_RS00080 14219..15349 + 1131 WP_001118464.1 molecular chaperone DnaJ -
ECOK1_RS00085 15454..15606 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15655..15712 + 58 - - Antitoxin
ECOK1_RS00090 16218..16979 + 762 WP_001274823.1 hypothetical protein -
ECOK1_RS00095 16999..18492 + 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
ECOK1_RS00100 18621..19880 + 1260 WP_000494925.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T27218 WP_000809168.1 NC_017628:c15606-15454 [Escherichia coli IHE3034]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T27218 NC_017628:c15606-15454 [Escherichia coli IHE3034]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT27218 NC_017628:15655-15712 [Escherichia coli IHE3034]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References