Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3674317..3674974 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name higB Uniprot ID A0A808IF03
Locus tag PTC87_RS17495 Protein ID WP_033146338.1
Coordinates 3674317..3674616 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808ICP3
Locus tag PTC87_RS17500 Protein ID WP_033146339.1
Coordinates 3674627..3674974 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS17485 (PTC87_17485) 3670685..3672883 + 2199 WP_033146337.1 type I secretion system permease/ATPase -
PTC87_RS17490 (PTC87_17490) 3672894..3674063 + 1170 WP_086374946.1 HlyD family efflux transporter periplasmic adaptor subunit -
PTC87_RS17495 (PTC87_17495) 3674317..3674616 + 300 WP_033146338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC87_RS17500 (PTC87_17500) 3674627..3674974 + 348 WP_033146339.1 HigA family addiction module antitoxin Antitoxin
PTC87_RS17505 (PTC87_17505) 3675019..3675444 + 426 WP_033146340.1 nucleoside triphosphatase NudI -
PTC87_RS17510 (PTC87_17510) 3675416..3676147 - 732 WP_033146341.1 helix-turn-helix transcriptional regulator -
PTC87_RS17515 (PTC87_17515) 3676245..3676664 + 420 WP_033146342.1 nuclear transport factor 2 family protein -
PTC87_RS17520 (PTC87_17520) 3676667..3677185 - 519 WP_033146343.1 hypothetical protein -
PTC87_RS17525 (PTC87_17525) 3677270..3678451 - 1182 WP_033146344.1 PLP-dependent aminotransferase family protein -
PTC87_RS17530 (PTC87_17530) 3678471..3679358 - 888 WP_033146345.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11691.32 Da        Isoelectric Point: 10.0346

>T272172 WP_033146338.1 NZ_CP117723:3674317-3674616 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.02 Da        Isoelectric Point: 7.0134

>AT272172 WP_033146339.1 NZ_CP117723:3674627-3674974 [Enterobacter asburiae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IF03

Antitoxin

Source ID Structure
AlphaFold DB A0A808ICP3

References