Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3000730..3001390 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PTC87_RS14340 Protein ID WP_033145931.1
Coordinates 3001037..3001390 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag PTC87_RS14335 Protein ID WP_029741460.1
Coordinates 3000730..3001032 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS14305 (PTC87_14305) 2996639..2998000 + 1362 WP_003036316.1 HEPN/Toprim-associated domain-containing protein -
PTC87_RS14310 (PTC87_14310) 2998170..2998364 + 195 WP_080277779.1 hypothetical protein -
PTC87_RS14315 (PTC87_14315) 2998321..2998653 - 333 WP_033145927.1 type II toxin-antitoxin system PemK/MazF family toxin -
PTC87_RS14320 (PTC87_14320) 2998654..2998911 - 258 WP_033145928.1 antitoxin -
PTC87_RS14325 (PTC87_14325) 2999203..2999592 - 390 WP_033145929.1 RidA family protein -
PTC87_RS14330 (PTC87_14330) 2999734..3000654 + 921 WP_033145930.1 LysR family transcriptional regulator -
PTC87_RS14335 (PTC87_14335) 3000730..3001032 - 303 WP_029741460.1 XRE family transcriptional regulator Antitoxin
PTC87_RS14340 (PTC87_14340) 3001037..3001390 - 354 WP_033145931.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC87_RS14345 (PTC87_14345) 3001568..3002461 - 894 WP_033145932.1 LysR substrate-binding domain-containing protein -
PTC87_RS14350 (PTC87_14350) 3002632..3003240 + 609 WP_080277780.1 glutathione S-transferase family protein -
PTC87_RS14355 (PTC87_14355) 3003284..3004234 - 951 WP_023336219.1 HTH-type transcriptional regulator Cbl -
PTC87_RS14360 (PTC87_14360) 3004331..3005248 - 918 WP_033145933.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13577.40 Da        Isoelectric Point: 8.0361

>T272170 WP_033145931.1 NZ_CP117723:c3001390-3001037 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLDDTDRASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
MLCAGNKVGNERRFYDEMLLVADQEFTHWLDRLKERE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT272170 WP_029741460.1 NZ_CP117723:c3001032-3000730 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MX79

References