Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3991631..3991889 Replicon chromosome
Accession NZ_CP117720
Organism Escherichia coli strain B1W1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PTA75_RS19505 Protein ID WP_000809168.1
Coordinates 3991737..3991889 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3991631..3991688 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA75_RS19485 3986679..3988010 + 1332 Protein_3810 fimbria/pilus outer membrane usher protein -
PTA75_RS19490 3988023..3988981 + 959 Protein_3811 fimbrial family protein -
PTA75_RS19495 3989020..3989919 - 900 WP_001300855.1 transcriptional activator NhaR -
PTA75_RS19500 3989985..3991151 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3991631..3991688 - 58 - - Antitoxin
PTA75_RS19505 3991737..3991889 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PTA75_RS19510 3991993..3993123 - 1131 WP_001118464.1 molecular chaperone DnaJ -
PTA75_RS19515 3993212..3995128 - 1917 WP_000516131.1 molecular chaperone DnaK -
PTA75_RS19520 3995505..3995909 + 405 WP_000843559.1 DUF2541 family protein -
PTA75_RS19525 3995935..3996648 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T272146 WP_000809168.1 NZ_CP117720:3991737-3991889 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT272146 NZ_CP117720:c3991688-3991631 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References