Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4734099..4734701 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PTA69_RS23065 Protein ID WP_000897305.1
Coordinates 4734390..4734701 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTA69_RS23060 Protein ID WP_000356397.1
Coordinates 4734099..4734389 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS23035 (4730025) 4730025..4730927 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PTA69_RS23040 (4730924) 4730924..4731559 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PTA69_RS23045 (4731556) 4731556..4732485 + 930 WP_001749031.1 formate dehydrogenase accessory protein FdhE -
PTA69_RS23050 (4732815) 4732815..4733057 - 243 WP_001086388.1 protein YiiF -
PTA69_RS23055 (4733276) 4733276..4733494 - 219 WP_001295676.1 CopG family transcriptional regulator -
PTA69_RS23060 (4734099) 4734099..4734389 - 291 WP_000356397.1 NadS family protein Antitoxin
PTA69_RS23065 (4734390) 4734390..4734701 - 312 WP_000897305.1 hypothetical protein Toxin
PTA69_RS23070 (4734930) 4734930..4735838 + 909 WP_001162704.1 alpha/beta hydrolase -
PTA69_RS23075 (4735902) 4735902..4736843 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
PTA69_RS23080 (4736888) 4736888..4737325 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PTA69_RS23085 (4737322) 4737322..4738194 - 873 WP_000920762.1 virulence factor BrkB family protein -
PTA69_RS23090 (4738188) 4738188..4738787 - 600 WP_001295269.1 glucose-1-phosphatase -
PTA69_RS23095 (4738886) 4738886..4739671 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T272121 WP_000897305.1 NZ_CP117717:c4734701-4734390 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT272121 WP_000356397.1 NZ_CP117717:c4734389-4734099 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References