Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3895665..3896206 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag PTA69_RS19205 Protein ID WP_000615982.1
Coordinates 3895928..3896206 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PTA69_RS19200 Protein ID WP_000729704.1
Coordinates 3895665..3895925 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS19175 (3891448) 3891448..3892233 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
PTA69_RS19180 (3892205) 3892205..3893917 + 1713 Protein_3760 flagellar biosynthesis protein FlhA -
PTA69_RS19185 (3894022) 3894022..3894300 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
PTA69_RS19190 (3894293) 3894293..3894649 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
PTA69_RS19195 (3894706) 3894706..3895479 - 774 WP_000543899.1 C40 family peptidase -
PTA69_RS19200 (3895665) 3895665..3895925 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PTA69_RS19205 (3895928) 3895928..3896206 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PTA69_RS19210 (3896362) 3896362..3897102 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PTA69_RS19215 (3897073) 3897073..3897840 - 768 WP_000333380.1 class II glutamine amidotransferase -
PTA69_RS19220 (3898046) 3898046..3898624 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T272119 WP_000615982.1 NZ_CP117717:3895928-3896206 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT272119 WP_000729704.1 NZ_CP117717:3895665-3895925 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References