Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 589804..590603 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag PTA69_RS02885 Protein ID WP_000347267.1
Coordinates 589804..590268 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PTA69_RS02890 Protein ID WP_001307405.1
Coordinates 590268..590603 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS02855 (584805) 584805..585239 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PTA69_RS02860 (585257) 585257..586135 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PTA69_RS02865 (586125) 586125..586904 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PTA69_RS02870 (586915) 586915..587388 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PTA69_RS02875 (587411) 587411..588691 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
PTA69_RS02880 (588940) 588940..589749 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PTA69_RS02885 (589804) 589804..590268 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PTA69_RS02890 (590268) 590268..590603 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PTA69_RS02895 (590752) 590752..592323 - 1572 WP_001273741.1 galactarate dehydratase -
PTA69_RS02900 (592698) 592698..594032 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PTA69_RS02905 (594048) 594048..594818 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 589804..601591 11787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T272107 WP_000347267.1 NZ_CP117717:c590268-589804 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT272107 WP_001307405.1 NZ_CP117717:c590603-590268 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References