Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4675026..4675628 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PTA50_RS22615 Protein ID WP_000897305.1
Coordinates 4675317..4675628 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTA50_RS22610 Protein ID WP_000356397.1
Coordinates 4675026..4675316 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS22585 (4670951) 4670951..4671853 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PTA50_RS22590 (4671850) 4671850..4672485 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PTA50_RS22595 (4672482) 4672482..4673411 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PTA50_RS22600 (4673741) 4673741..4673983 - 243 WP_001087409.1 protein YiiF -
PTA50_RS22605 (4674203) 4674203..4674421 - 219 WP_001315930.1 CopG family transcriptional regulator -
PTA50_RS22610 (4675026) 4675026..4675316 - 291 WP_000356397.1 NadS family protein Antitoxin
PTA50_RS22615 (4675317) 4675317..4675628 - 312 WP_000897305.1 hypothetical protein Toxin
PTA50_RS22620 (4675857) 4675857..4676765 + 909 WP_001162704.1 alpha/beta hydrolase -
PTA50_RS22625 (4676829) 4676829..4677770 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PTA50_RS22630 (4677815) 4677815..4678252 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PTA50_RS22635 (4678249) 4678249..4679121 - 873 WP_000920762.1 virulence factor BrkB family protein -
PTA50_RS22640 (4679115) 4679115..4679714 - 600 WP_001295269.1 glucose-1-phosphatase -
PTA50_RS22645 (4679813) 4679813..4680598 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T272096 WP_000897305.1 NZ_CP117714:c4675628-4675317 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT272096 WP_000356397.1 NZ_CP117714:c4675316-4675026 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References