Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 596748..597547 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6H2GMC5
Locus tag PTA50_RS02935 Protein ID WP_000347279.1
Coordinates 596748..597212 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PTA50_RS02940 Protein ID WP_001307405.1
Coordinates 597212..597547 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS02905 (591749) 591749..592183 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PTA50_RS02910 (592201) 592201..593079 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
PTA50_RS02915 (593069) 593069..593848 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PTA50_RS02920 (593859) 593859..594332 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PTA50_RS02925 (594355) 594355..595635 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
PTA50_RS02930 (595884) 595884..596693 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PTA50_RS02935 (596748) 596748..597212 - 465 WP_000347279.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PTA50_RS02940 (597212) 597212..597547 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PTA50_RS02945 (597696) 597696..599267 - 1572 WP_001273741.1 galactarate dehydratase -
PTA50_RS02950 (599642) 599642..600976 + 1335 WP_128995326.1 galactarate/glucarate/glycerate transporter GarP -
PTA50_RS02955 (600992) 600992..601762 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17869.24 Da        Isoelectric Point: 9.4947

>T272079 WP_000347279.1 NZ_CP117714:c597212-596748 [Escherichia coli]
MDFPQRVNGWVLYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESFTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT272079 WP_001307405.1 NZ_CP117714:c597547-597212 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GMC5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References