272075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2997922..2998430 Replicon chromosome
Accession NZ_CP117709
Organism Streptomyces sp. MMBL 11-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag PSQ21_RS12835 Protein ID WP_274030628.1
Coordinates 2998170..2998430 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID V6U6C9
Locus tag PSQ21_RS12830 Protein ID WP_006125193.1
Coordinates 2997922..2998173 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSQ21_RS12820 2994233..2995894 - 1662 WP_274030626.1 PQQ-binding-like beta-propeller repeat protein -
PSQ21_RS12825 2995962..2997782 - 1821 WP_274030627.1 ABC-F family ATP-binding cassette domain-containing protein -
PSQ21_RS12830 2997922..2998173 + 252 WP_006125193.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PSQ21_RS12835 2998170..2998430 + 261 WP_274030628.1 Txe/YoeB family addiction module toxin Toxin
PSQ21_RS12840 2998843..2999364 + 522 WP_274030629.1 PASTA domain-containing protein -
PSQ21_RS12845 2999420..3000325 - 906 WP_274035732.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PSQ21_RS12850 3000331..3001203 - 873 WP_274030630.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
PSQ21_RS12855 3001279..3002145 - 867 WP_274030632.1 TatD family hydrolase -
PSQ21_RS12860 3002305..3002676 - 372 WP_274030633.1 hypothetical protein -
PSQ21_RS12865 3003130..3003306 + 177 WP_274030634.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 87 a.a.        Molecular weight: 10414.70 Da        Isoelectric Point: 8.8783

>T272075 WP_274030628.1 NZ_CP117709:2998170-2998430 [Streptomyces sp. MMBL 11-1]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFHGYWSRRITDEHRLIYKVADDEVRVAAC
RYHYGH

Download         Length: 261 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9272.34 Da        Isoelectric Point: 4.4118

>AT272075 WP_006125193.1 NZ_CP117709:2997922-2998173 [Streptomyces sp. MMBL 11-1]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLESGGGTVQE
LAE

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB V6U6C9

References