Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4489508..4490110 Replicon chromosome
Accession NZ_CP117698
Organism Salmonella enterica subsp. enterica serovar London strain L1

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PRJ38_RS21610 Protein ID WP_001159635.1
Coordinates 4489799..4490110 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PRJ38_RS21605 Protein ID WP_000362050.1
Coordinates 4489508..4489798 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ38_RS21590 (4487001) 4487001..4487903 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PRJ38_RS21595 (4487900) 4487900..4488535 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PRJ38_RS21600 (4488532) 4488532..4489461 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PRJ38_RS21605 (4489508) 4489508..4489798 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PRJ38_RS21610 (4489799) 4489799..4490110 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PRJ38_RS21615 (4490337) 4490337..4491557 - 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
PRJ38_RS21620 (4491652) 4491652..4492581 + 930 WP_023255277.1 alpha/beta hydrolase -
PRJ38_RS21625 (4492667) 4492667..4492978 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
PRJ38_RS21630 (4492975) 4492975..4493421 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PRJ38_RS21635 (4493436) 4493436..4494377 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PRJ38_RS21640 (4494422) 4494422..4494859 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4490337..4491557 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T272072 WP_001159635.1 NZ_CP117698:c4490110-4489799 [Salmonella enterica subsp. enterica serovar London]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT272072 WP_000362050.1 NZ_CP117698:c4489798-4489508 [Salmonella enterica subsp. enterica serovar London]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References