272065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2299285..2299807 Replicon chromosome
Accession NZ_CP117698
Organism Salmonella enterica subsp. enterica serovar London strain L1

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PRJ38_RS11055 Protein ID WP_000221343.1
Coordinates 2299523..2299807 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PRJ38_RS11050 Protein ID WP_000885424.1
Coordinates 2299285..2299533 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ38_RS11025 (2295378) 2295378..2296844 + 1467 WP_077946914.1 hypothetical protein -
PRJ38_RS11030 (2297146) 2297146..2297436 + 291 WP_000742001.1 hypothetical protein -
PRJ38_RS11035 (2297789) 2297789..2298515 + 727 Protein_2157 helix-turn-helix domain-containing protein -
PRJ38_RS11040 (2298596) 2298596..2298928 - 333 WP_000253154.1 DUF1493 family protein -
PRJ38_RS11045 (2298918) 2298918..2299133 - 216 WP_000206207.1 hypothetical protein -
PRJ38_RS11050 (2299285) 2299285..2299533 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PRJ38_RS11055 (2299523) 2299523..2299807 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRJ38_RS11060 (2299978) 2299978..2300367 + 390 WP_000194089.1 RidA family protein -
PRJ38_RS11065 (2300419) 2300419..2301498 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PRJ38_RS11070 (2301691) 2301691..2302179 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PRJ38_RS11075 (2302224) 2302224..2303732 + 1509 WP_058214747.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2295381..2306589 11208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T272065 WP_000221343.1 NZ_CP117698:2299523-2299807 [Salmonella enterica subsp. enterica serovar London]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT272065 WP_000885424.1 NZ_CP117698:2299285-2299533 [Salmonella enterica subsp. enterica serovar London]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References