Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4598522..4599124 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PTQ18_RS22205 Protein ID WP_001159635.1
Coordinates 4598813..4599124 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PTQ18_RS22200 Protein ID WP_000362050.1
Coordinates 4598522..4598812 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS22185 (4596015) 4596015..4596917 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PTQ18_RS22190 (4596914) 4596914..4597549 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PTQ18_RS22195 (4597546) 4597546..4598475 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PTQ18_RS22200 (4598522) 4598522..4598812 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PTQ18_RS22205 (4598813) 4598813..4599124 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PTQ18_RS22210 (4599351) 4599351..4600571 - 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
PTQ18_RS22215 (4600666) 4600666..4601595 + 930 WP_023255277.1 alpha/beta hydrolase -
PTQ18_RS22220 (4601681) 4601681..4601992 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
PTQ18_RS22225 (4601989) 4601989..4602435 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PTQ18_RS22230 (4602450) 4602450..4603391 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PTQ18_RS22235 (4603436) 4603436..4603873 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4599351..4600571 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T272038 WP_001159635.1 NZ_CP117693:c4599124-4598813 [Salmonella enterica subsp. enterica serovar London]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT272038 WP_000362050.1 NZ_CP117693:c4598812-4598522 [Salmonella enterica subsp. enterica serovar London]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References