Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2783532..2784244 Replicon chromosome
Accession NZ_CP117678
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS033_RS13975 Protein ID WP_000162413.1
Coordinates 2783532..2783834 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS033_RS13980 Protein ID WP_000806446.1
Coordinates 2783906..2784244 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS13955 (2780395) 2780395..2781237 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS033_RS13960 (2781309) 2781309..2782661 + 1353 WP_054410173.1 glutathione-disulfide reductase -
PS033_RS13965 (2782715) 2782715..2782798 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS033_RS13970 (2782874) 2782874..2783368 - 495 WP_059267928.1 hypothetical protein -
PS033_RS13975 (2783532) 2783532..2783834 + 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS033_RS13980 (2783906) 2783906..2784244 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS033_RS13985 (2784301) 2784301..2784480 + 180 WP_002460167.1 hypothetical protein -
PS033_RS13990 (2784817) 2784817..2785383 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS033_RS13995 (2785530) 2785530..2786060 + 531 WP_059267927.1 LuxR C-terminal-related transcriptional regulator -
PS033_RS14000 (2786132) 2786132..2787160 - 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS033_RS14005 (2787209) 2787209..2789191 - 1983 WP_059220987.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T272011 WP_000162413.1 NZ_CP117678:2783532-2783834 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT272011 WP_000806446.1 NZ_CP117678:2783906-2784244 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References