Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 732728..733290 Replicon chromosome
Accession NZ_CP117678
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag PS033_RS03910 Protein ID WP_000605676.1
Coordinates 732728..733006 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS033_RS03915 Protein ID WP_000781370.1
Coordinates 733006..733290 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS03890 (728717) 728717..729148 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS033_RS03895 (729406) 729406..729543 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS033_RS03900 (729700) 729700..731397 + 1698 WP_000433442.1 malate dehydrogenase -
PS033_RS03905 (731532) 731532..732542 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS033_RS03910 (732728) 732728..733006 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS033_RS03915 (733006) 733006..733290 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS033_RS03920 (733518) 733518..734171 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS033_RS03925 (734164) 734164..735048 - 885 WP_059268408.1 formate dehydrogenase N subunit beta -
PS033_RS03930 (735061) 735061..738108 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T272008 WP_000605676.1 NZ_CP117678:732728-733006 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT272008 WP_000781370.1 NZ_CP117678:733006-733290 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References