Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4653015..4653617 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag PSR34_RS22690 Protein ID WP_000897305.1
Coordinates 4653306..4653617 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PSR34_RS22685 Protein ID WP_000356397.1
Coordinates 4653015..4653305 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS22660 (4648941) 4648941..4649843 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
PSR34_RS22665 (4649840) 4649840..4650475 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
PSR34_RS22670 (4650472) 4650472..4651401 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
PSR34_RS22675 (4651731) 4651731..4651973 - 243 WP_001086388.1 protein YiiF -
PSR34_RS22680 (4652192) 4652192..4652410 - 219 WP_001297075.1 CopG family transcriptional regulator -
PSR34_RS22685 (4653015) 4653015..4653305 - 291 WP_000356397.1 NadS family protein Antitoxin
PSR34_RS22690 (4653306) 4653306..4653617 - 312 WP_000897305.1 hypothetical protein Toxin
PSR34_RS22695 (4653846) 4653846..4654754 + 909 WP_001162704.1 alpha/beta hydrolase -
PSR34_RS22700 (4654818) 4654818..4655759 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
PSR34_RS22705 (4655804) 4655804..4656241 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
PSR34_RS22710 (4656238) 4656238..4657110 - 873 WP_000920762.1 virulence factor BrkB family protein -
PSR34_RS22715 (4657104) 4657104..4657703 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T271995 WP_000897305.1 NZ_CP117672:c4653617-4653306 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT271995 WP_000356397.1 NZ_CP117672:c4653305-4653015 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References