Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3788852..3789393 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag PSR34_RS18600 Protein ID WP_000615976.1
Coordinates 3789115..3789393 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag PSR34_RS18595 Protein ID WP_000729704.1
Coordinates 3788852..3789112 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS18570 (3784635) 3784635..3785420 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
PSR34_RS18575 (3785392) 3785392..3787104 + 1713 Protein_3635 flagellar biosynthesis protein FlhA -
PSR34_RS18580 (3787209) 3787209..3787487 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
PSR34_RS18585 (3787480) 3787480..3787836 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
PSR34_RS18590 (3787893) 3787893..3788666 - 774 WP_000543899.1 C40 family peptidase -
PSR34_RS18595 (3788852) 3788852..3789112 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
PSR34_RS18600 (3789115) 3789115..3789393 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
PSR34_RS18605 (3789549) 3789549..3790289 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
PSR34_RS18610 (3790260) 3790260..3791027 - 768 WP_000333380.1 class II glutamine amidotransferase -
PSR34_RS18615 (3791233) 3791233..3791811 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA 3736670..3813605 76935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T271992 WP_000615976.1 NZ_CP117672:3789115-3789393 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT271992 WP_000729704.1 NZ_CP117672:3788852-3789112 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References