Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 594341..595140 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag PSR34_RS02930 Protein ID WP_000347267.1
Coordinates 594341..594805 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PSR34_RS02935 Protein ID WP_001307405.1
Coordinates 594805..595140 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS02900 (589342) 589342..589776 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PSR34_RS02905 (589794) 589794..590672 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
PSR34_RS02910 (590662) 590662..591441 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PSR34_RS02915 (591452) 591452..591925 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PSR34_RS02920 (591948) 591948..593228 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
PSR34_RS02925 (593477) 593477..594286 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PSR34_RS02930 (594341) 594341..594805 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PSR34_RS02935 (594805) 594805..595140 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PSR34_RS02940 (595289) 595289..596860 - 1572 WP_001273741.1 galactarate dehydratase -
PSR34_RS02945 (597235) 597235..598569 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
PSR34_RS02950 (598585) 598585..599355 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T271981 WP_000347267.1 NZ_CP117672:c594805-594341 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT271981 WP_001307405.1 NZ_CP117672:c595140-594805 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References