Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 4048773..4049467 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PS054_RS19905 Protein ID WP_001263500.1
Coordinates 4049069..4049467 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PS054_RS19900 Protein ID WP_000554758.1
Coordinates 4048773..4049066 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS19880 (4044472) 4044472..4044969 + 498 WP_095573642.1 REP-associated tyrosine transposase RayT -
PS054_RS19885 (4045085) 4045085..4046797 - 1713 Protein_3872 flagellar biosynthesis protein FlhA -
PS054_RS19890 (4046769) 4046769..4047536 + 768 WP_072243690.1 putative lateral flagellar export/assembly protein LafU -
PS054_RS19895 (4047666) 4047666..4048721 + 1056 WP_059217800.1 DNA polymerase IV -
PS054_RS19900 (4048773) 4048773..4049066 + 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PS054_RS19905 (4049069) 4049069..4049467 + 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PS054_RS19910 (4049477) 4049477..4049929 + 453 WP_095575504.1 GNAT family N-acetyltransferase -
PS054_RS19915 (4049942) 4049942..4050541 + 600 WP_072249376.1 peptide chain release factor H -
PS054_RS19920 (4050557) 4050557..4050679 + 123 Protein_3879 metal-dependent hydrolase -
PS054_RS19925 (4050682) 4050682..4050924 - 243 WP_059222190.1 hypothetical protein -
PS054_RS19930 (4050983) 4050983..4052440 - 1458 WP_273814186.1 cytosol nonspecific dipeptidase -
PS054_RS19935 (4052701) 4052701..4053159 + 459 WP_001291989.1 xanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T271972 WP_001263500.1 NZ_CP117668:4049069-4049467 [Escherichia albertii]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT271972 WP_000554758.1 NZ_CP117668:4048773-4049066 [Escherichia albertii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References