Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2810434..2811146 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS054_RS14135 Protein ID WP_113650514.1
Coordinates 2810434..2810736 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS054_RS14140 Protein ID WP_000806446.1
Coordinates 2810808..2811146 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS14110 (2807097) 2807097..2807939 + 843 WP_113650511.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS054_RS14115 (2808011) 2808011..2809363 + 1353 WP_113650512.1 glutathione-disulfide reductase -
PS054_RS14120 (2809417) 2809417..2809500 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS054_RS14125 (2809528) 2809528..2809701 + 174 WP_000553433.1 hypothetical protein -
PS054_RS14130 (2809980) 2809980..2810270 - 291 WP_113650513.1 hypothetical protein -
PS054_RS14135 (2810434) 2810434..2810736 + 303 WP_113650514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS054_RS14140 (2810808) 2810808..2811146 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS054_RS14145 (2811203) 2811203..2811370 + 168 WP_273813853.1 hypothetical protein -
PS054_RS14150 (2811719) 2811719..2812285 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS054_RS14155 (2812432) 2812432..2812962 + 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS054_RS14160 (2813034) 2813034..2814062 - 1029 WP_273813856.1 hematinate-forming heme oxygenase ChuS -
PS054_RS14165 (2814111) 2814111..2816093 - 1983 WP_059220987.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11870.60 Da        Isoelectric Point: 10.0443

>T271964 WP_113650514.1 NZ_CP117668:2810434-2810736 [Escherichia albertii]
MTKKINIKNFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271964 WP_000806446.1 NZ_CP117668:2810808-2811146 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References