Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 233117..233829 Replicon chromosome
Accession NZ_CP117659
Organism Escherichia albertii strain BIA_13

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS034_RS01050 Protein ID WP_000162413.1
Coordinates 233527..233829 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS034_RS01045 Protein ID WP_000806447.1
Coordinates 233117..233455 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS034_RS01020 (228160) 228160..230142 + 1983 WP_059228480.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS034_RS01025 (230191) 230191..231219 + 1029 WP_273822412.1 hematinate-forming heme oxygenase ChuS -
PS034_RS01030 (231291) 231291..231821 - 531 WP_059257619.1 LuxR C-terminal-related transcriptional regulator -
PS034_RS01035 (231968) 231968..232534 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS034_RS01040 (232881) 232881..233060 - 180 WP_002460167.1 hypothetical protein -
PS034_RS01045 (233117) 233117..233455 - 339 WP_000806447.1 HigA family addiction module antitoxin Antitoxin
PS034_RS01050 (233527) 233527..233829 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS034_RS01055 (233993) 233993..234472 + 480 WP_107193136.1 hypothetical protein -
PS034_RS01060 (234562) 234562..234735 - 174 WP_000553433.1 hypothetical protein -
PS034_RS01065 (234763) 234763..234846 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS034_RS01070 (234900) 234900..236252 - 1353 WP_000160823.1 glutathione-disulfide reductase -
PS034_RS01075 (236324) 236324..237166 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271919 WP_000162413.1 NZ_CP117659:c233829-233527 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13010.90 Da        Isoelectric Point: 5.2075

>AT271919 WP_000806447.1 NZ_CP117659:c233455-233117 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNSRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References