Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3974211..3974469 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag PS036_RS19835 Protein ID WP_000809168.1
Coordinates 3974317..3974469 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3974211..3974268 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS19820 3970219..3971447 + 1229 WP_089541817.1 IS3 family transposase -
PS036_RS19825 3971372..3972913 - 1542 WP_273810779.1 sulfatase-like hydrolase/transferase -
PS036_RS19830 3972934..3973695 - 762 WP_059275866.1 outer membrane protein OmpK -
- 3974211..3974268 - 58 - - Antitoxin
PS036_RS19835 3974317..3974469 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
PS036_RS19840 3974547..3975658 + 1112 Protein_3873 IS4-like element IS421 family transposase -
PS036_RS19845 3975921..3977051 - 1131 WP_001118445.1 molecular chaperone DnaJ -
PS036_RS19850 3977140..3979056 - 1917 WP_000516135.1 molecular chaperone DnaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3970219..3975821 5602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T271904 WP_000809168.1 NZ_CP117654:3974317-3974469 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT271904 NZ_CP117654:c3974268-3974211 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References