Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3715296..3715990 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PS036_RS18570 Protein ID WP_001263500.1
Coordinates 3715296..3715694 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PS036_RS18575 Protein ID WP_000554758.1
Coordinates 3715697..3715990 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS18540 (3711604) 3711604..3712062 - 459 WP_273810775.1 xanthine phosphoribosyltransferase -
PS036_RS18545 (3712323) 3712323..3713780 + 1458 WP_001292996.1 cytosol nonspecific dipeptidase -
PS036_RS18550 (3713839) 3713839..3714081 + 243 WP_059222190.1 hypothetical protein -
PS036_RS18555 (3714084) 3714084..3714206 - 123 Protein_3623 metal-dependent hydrolase -
PS036_RS18560 (3714222) 3714222..3714821 - 600 WP_072248949.1 peptide chain release factor H -
PS036_RS18565 (3714834) 3714834..3715286 - 453 WP_072243685.1 GNAT family N-acetyltransferase -
PS036_RS18570 (3715296) 3715296..3715694 - 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PS036_RS18575 (3715697) 3715697..3715990 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PS036_RS18580 (3716042) 3716042..3717097 - 1056 WP_059217800.1 DNA polymerase IV -
PS036_RS18585 (3717227) 3717227..3717994 - 768 WP_072243690.1 putative lateral flagellar export/assembly protein LafU -
PS036_RS18590 (3717966) 3717966..3719678 + 1713 Protein_3630 flagellar biosynthesis protein FlhA -
PS036_RS18595 (3719794) 3719794..3720291 - 498 WP_059275984.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA / IlpA 3714834..3753240 38406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T271903 WP_001263500.1 NZ_CP117654:c3715694-3715296 [Escherichia albertii]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT271903 WP_000554758.1 NZ_CP117654:c3715990-3715697 [Escherichia albertii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References