Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2353553..2354115 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS036_RS11645 Protein ID WP_059276333.1
Coordinates 2353553..2353831 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS036_RS11650 Protein ID WP_000781370.1
Coordinates 2353831..2354115 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS11625 (2349548) 2349548..2349979 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS036_RS11630 (2350237) 2350237..2350374 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS036_RS11635 (2350525) 2350525..2352222 + 1698 WP_000433442.1 malate dehydrogenase -
PS036_RS11640 (2352357) 2352357..2353367 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS036_RS11645 (2353553) 2353553..2353831 + 279 WP_059276333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS036_RS11650 (2353831) 2353831..2354115 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS036_RS11655 (2354344) 2354344..2354997 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS036_RS11660 (2354990) 2354990..2355874 - 885 WP_059268408.1 formate dehydrogenase N subunit beta -
PS036_RS11665 (2355887) 2355887..2358934 - 3048 WP_077870794.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10481.08 Da        Isoelectric Point: 7.2751

>T271896 WP_059276333.1 NZ_CP117654:2353553-2353831 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271896 WP_000781370.1 NZ_CP117654:2353831-2354115 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References