Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 233726..234438 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS036_RS01060 Protein ID WP_000162413.1
Coordinates 234136..234438 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS036_RS01055 Protein ID WP_000806446.1
Coordinates 233726..234064 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS01030 (228779) 228779..230761 + 1983 WP_059275469.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS036_RS01035 (230810) 230810..231838 + 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS036_RS01040 (231910) 231910..232440 - 531 WP_059275470.1 LuxR C-terminal-related transcriptional regulator -
PS036_RS01045 (232587) 232587..233153 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS036_RS01050 (233490) 233490..233669 - 180 WP_002460167.1 hypothetical protein -
PS036_RS01055 (233726) 233726..234064 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS036_RS01060 (234136) 234136..234438 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS036_RS01065 (234602) 234602..235096 + 495 WP_059267928.1 hypothetical protein -
PS036_RS01070 (235172) 235172..235255 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS036_RS01075 (235309) 235309..236661 - 1353 WP_054410173.1 glutathione-disulfide reductase -
PS036_RS01080 (236733) 236733..237575 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS036_RS01085 (237756) 237756..238766 + 1011 WP_059275471.1 YwqG family protein -
PS036_RS01090 (238776) 238776..239237 - 462 WP_105632917.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271888 WP_000162413.1 NZ_CP117654:c234438-234136 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271888 WP_000806446.1 NZ_CP117654:c234064-233726 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References