Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3948404..3949098 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name yafO Uniprot ID S1PJQ2
Locus tag PS055_RS19090 Protein ID WP_001263500.1
Coordinates 3948700..3949098 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag PS055_RS19085 Protein ID WP_000554758.1
Coordinates 3948404..3948697 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS19065 (3944103) 3944103..3944600 + 498 WP_059222192.1 transposase -
PS055_RS19070 (3944716) 3944716..3946428 - 1713 Protein_3710 flagellar biosynthesis protein FlhA -
PS055_RS19075 (3946400) 3946400..3947167 + 768 WP_072243690.1 putative lateral flagellar export/assembly protein LafU -
PS055_RS19080 (3947297) 3947297..3948352 + 1056 WP_059217800.1 DNA polymerase IV -
PS055_RS19085 (3948404) 3948404..3948697 + 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
PS055_RS19090 (3948700) 3948700..3949098 + 399 WP_001263500.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
PS055_RS19095 (3949108) 3949108..3949560 + 453 WP_072243685.1 GNAT family N-acetyltransferase -
PS055_RS19100 (3949573) 3949573..3950172 + 600 WP_072243684.1 peptide chain release factor H -
PS055_RS19105 (3950188) 3950188..3950310 + 123 Protein_3717 metal-dependent hydrolase -
PS055_RS19110 (3950313) 3950313..3950555 - 243 WP_059222190.1 hypothetical protein -
PS055_RS19115 (3950614) 3950614..3952071 - 1458 WP_001292996.1 cytosol nonspecific dipeptidase -
PS055_RS19120 (3952332) 3952332..3952790 + 459 WP_001291989.1 xanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15413.85 Da        Isoelectric Point: 8.9511

>T271883 WP_001263500.1 NZ_CP117650:3948700-3949098 [Escherichia albertii]
MRVFKTKLIRLQLTAEELEALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDAAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT271883 WP_000554758.1 NZ_CP117650:3948404-3948697 [Escherichia albertii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PJQ2

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References