Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2723785..2724497 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS055_RS13385 Protein ID WP_059220983.1
Coordinates 2723785..2724087 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS055_RS13390 Protein ID WP_000806446.1
Coordinates 2724159..2724497 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS13370 (2720648) 2720648..2721490 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS055_RS13375 (2721562) 2721562..2722914 + 1353 WP_059220981.1 glutathione-disulfide reductase -
PS055_RS13380 (2722968) 2722968..2723051 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS055_RS13385 (2723785) 2723785..2724087 + 303 WP_059220983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS055_RS13390 (2724159) 2724159..2724497 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS055_RS13395 (2724554) 2724554..2724733 + 180 WP_002460167.1 hypothetical protein -
PS055_RS13400 (2725070) 2725070..2725636 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS055_RS13405 (2725783) 2725783..2726313 + 531 WP_059220985.1 LuxR C-terminal-related transcriptional regulator -
PS055_RS13410 (2726385) 2726385..2727413 - 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS055_RS13415 (2727462) 2727462..2729444 - 1983 WP_059220987.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11885.61 Da        Isoelectric Point: 9.8664

>T271880 WP_059220983.1 NZ_CP117650:2723785-2724087 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNDYSSIRVNNQYR
LIFKWVNGKAEDLYLAPHKY

Download         Length: 303 bp

>T271880 NZ_CP117650:2723785-2724087 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGACTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGCCCCTCACAAATACTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271880 WP_000806446.1 NZ_CP117650:2724159-2724497 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp

>AT271880 NZ_CP117650:2724159-2724497 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References