Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 647039..647601 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS055_RS03165 Protein ID WP_059221880.1
Coordinates 647323..647601 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS055_RS03160 Protein ID WP_000781370.1
Coordinates 647039..647323 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS03145 (642220) 642220..645267 + 3048 WP_077871680.1 formate dehydrogenase-N subunit alpha -
PS055_RS03150 (645280) 645280..646164 + 885 WP_059221881.1 formate dehydrogenase N subunit beta -
PS055_RS03155 (646157) 646157..646810 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS055_RS03160 (647039) 647039..647323 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS055_RS03165 (647323) 647323..647601 - 279 WP_059221880.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS055_RS03170 (647787) 647787..648797 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS055_RS03175 (648932) 648932..650629 - 1698 WP_000433442.1 malate dehydrogenase -
PS055_RS03180 (650786) 650786..650923 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS055_RS03185 (651181) 651181..651612 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10480.14 Da        Isoelectric Point: 8.9374

>T271871 WP_059221880.1 NZ_CP117650:c647601-647323 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYLLDYKDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271871 WP_000781370.1 NZ_CP117650:c647323-647039 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References