Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3669114..3669764 Replicon chromosome
Accession NZ_CP117647
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS048_RS18035 Protein ID WP_059224977.1
Coordinates 3669423..3669764 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag PS048_RS18030 Protein ID WP_025237546.1
Coordinates 3669114..3669413 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS18005 (3664471) 3664471..3664782 - 312 WP_000410252.1 hypothetical protein -
PS048_RS18010 (3664787) 3664787..3665179 - 393 WP_000273381.1 flagellar export chaperone FliS -
PS048_RS18015 (3665202) 3665202..3666518 - 1317 WP_000609691.1 flagellar filament capping protein FliD -
PS048_RS18020 (3666804) 3666804..3667718 - 915 WP_000949079.1 lateral flagellin LafA -
PS048_RS18025 (3668205) 3668205..3669056 + 852 WP_273784903.1 winged helix-turn-helix domain-containing protein -
PS048_RS18030 (3669114) 3669114..3669413 - 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
PS048_RS18035 (3669423) 3669423..3669764 - 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS048_RS18040 (3669840) 3669840..3670817 - 978 WP_273784907.1 flagellar hook-associated protein -
PS048_RS18045 (3670834) 3670834..3671763 - 930 WP_025237548.1 flagellar hook-associated protein FlgL -
PS048_RS18050 (3671778) 3671778..3673154 - 1377 WP_131109687.1 flagellar hook-associated protein FlgK -
PS048_RS18055 (3673594) 3673594..3673893 - 300 WP_059254376.1 rod-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T271857 WP_059224977.1 NZ_CP117647:c3669764-3669423 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT271857 WP_025237546.1 NZ_CP117647:c3669413-3669114 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References