Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2416300..2416862 Replicon chromosome
Accession NZ_CP117647
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag PS048_RS11835 Protein ID WP_000605679.1
Coordinates 2416300..2416578 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS048_RS11840 Protein ID WP_000781370.1
Coordinates 2416578..2416862 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS11815 (2412280) 2412280..2412711 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS048_RS11820 (2412978) 2412978..2413115 + 138 Protein_2310 stationary-phase-induced ribosome-associated protein -
PS048_RS11825 (2413272) 2413272..2414969 + 1698 WP_000433442.1 malate dehydrogenase -
PS048_RS11830 (2415104) 2415104..2416114 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS048_RS11835 (2416300) 2416300..2416578 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS048_RS11840 (2416578) 2416578..2416862 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS048_RS11845 (2417090) 2417090..2417743 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS048_RS11850 (2417736) 2417736..2418620 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
PS048_RS11855 (2418633) 2418633..2421680 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T271855 WP_000605679.1 NZ_CP117647:2416300-2416578 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271855 WP_000781370.1 NZ_CP117647:2416578-2416862 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References