Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 261788..262500 Replicon chromosome
Accession NZ_CP117647
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS048_RS01215 Protein ID WP_273785504.1
Coordinates 262198..262500 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS048_RS01210 Protein ID WP_000806446.1
Coordinates 261788..262126 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS01185 (256827) 256827..258809 + 1983 WP_059236847.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS048_RS01190 (258858) 258858..259886 + 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS048_RS01195 (259958) 259958..260488 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS048_RS01200 (260635) 260635..261201 - 567 WP_059216822.1 outer membrane lipoprotein Slp -
PS048_RS01205 (261548) 261548..261697 - 150 WP_233991781.1 hypothetical protein -
PS048_RS01210 (261788) 261788..262126 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS048_RS01215 (262198) 262198..262500 - 303 WP_273785504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS048_RS01220 (262664) 262664..263143 + 480 WP_273785506.1 hypothetical protein -
PS048_RS01225 (263233) 263233..263406 - 174 WP_044708027.1 hypothetical protein -
PS048_RS01230 (263434) 263434..263517 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS048_RS01235 (263571) 263571..264923 - 1353 WP_273785509.1 glutathione-disulfide reductase -
PS048_RS01240 (264995) 264995..265837 - 843 WP_044708024.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11870.60 Da        Isoelectric Point: 10.0443

>T271844 WP_273785504.1 NZ_CP117647:c262500-262198 [Escherichia albertii]
MTKKINIKDFRNAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271844 WP_000806446.1 NZ_CP117647:c262126-261788 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References