Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3778460..3779110 Replicon chromosome
Accession NZ_CP117643
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS043_RS19090 Protein ID WP_059224977.1
Coordinates 3778460..3778801 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag PS043_RS19095 Protein ID WP_025237546.1
Coordinates 3778811..3779110 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS19070 (3774213) 3774213..3774512 + 300 WP_273816510.1 rod-binding protein -
PS043_RS19075 (3775070) 3775070..3776446 + 1377 WP_137653778.1 flagellar hook-associated protein FlgK -
PS043_RS19080 (3776461) 3776461..3777390 + 930 WP_001266795.1 flagellar hook-associated protein FlgL -
PS043_RS19085 (3777407) 3777407..3778384 + 978 WP_059258863.1 hypothetical protein -
PS043_RS19090 (3778460) 3778460..3778801 + 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS043_RS19095 (3778811) 3778811..3779110 + 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
PS043_RS19100 (3779168) 3779168..3780019 - 852 WP_059258865.1 winged helix-turn-helix domain-containing protein -
PS043_RS19105 (3780506) 3780506..3781420 + 915 WP_000949079.1 lateral flagellin LafA -
PS043_RS19110 (3781729) 3781729..3783045 + 1317 WP_273816512.1 flagellar filament capping protein FliD -
PS043_RS19115 (3783068) 3783068..3783460 + 393 WP_273816513.1 flagellar export chaperone FliS -
PS043_RS19120 (3783465) 3783465..3783776 + 312 WP_000410252.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T271827 WP_059224977.1 NZ_CP117643:3778460-3778801 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT271827 WP_025237546.1 NZ_CP117643:3778811-3779110 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References