Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2466237..2466799 Replicon chromosome
Accession NZ_CP117643
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag PS043_RS12550 Protein ID WP_000605679.1
Coordinates 2466237..2466515 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag PS043_RS12555 Protein ID WP_000781370.1
Coordinates 2466515..2466799 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS12530 (2462217) 2462217..2462648 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS043_RS12535 (2462915) 2462915..2463052 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS043_RS12540 (2463209) 2463209..2464906 + 1698 WP_000433442.1 malate dehydrogenase -
PS043_RS12545 (2465041) 2465041..2466051 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS043_RS12550 (2466237) 2466237..2466515 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS043_RS12555 (2466515) 2466515..2466799 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
PS043_RS12560 (2467028) 2467028..2467681 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS043_RS12565 (2467674) 2467674..2468558 - 885 WP_273816209.1 formate dehydrogenase N subunit beta -
PS043_RS12570 (2468571) 2468571..2471618 - 3048 WP_098402488.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T271825 WP_000605679.1 NZ_CP117643:2466237-2466515 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT271825 WP_000781370.1 NZ_CP117643:2466515-2466799 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References