Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2534432..2534994 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS040_RS12605 Protein ID WP_149507449.1
Coordinates 2534432..2534710 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag PS040_RS12610 Protein ID WP_021528209.1
Coordinates 2534710..2534994 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS12585 (2530412) 2530412..2530843 - 432 WP_000152289.1 peroxiredoxin OsmC -
PS040_RS12590 (2531110) 2531110..2531247 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
PS040_RS12595 (2531404) 2531404..2533101 + 1698 WP_273782138.1 malate dehydrogenase -
PS040_RS12600 (2533236) 2533236..2534246 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
PS040_RS12605 (2534432) 2534432..2534710 + 279 WP_149507449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS040_RS12610 (2534710) 2534710..2534994 + 285 WP_021528209.1 HigA family addiction module antitoxin Antitoxin
PS040_RS12615 (2535222) 2535222..2535875 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
PS040_RS12620 (2535868) 2535868..2536752 - 885 WP_273782139.1 formate dehydrogenase N subunit beta -
PS040_RS12625 (2536765) 2536765..2539812 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10520.12 Da        Isoelectric Point: 8.0733

>T271800 WP_149507449.1 NZ_CP117637:2534432-2534710 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GNAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT271800 WP_021528209.1 NZ_CP117637:2534710-2534994 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References