Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 642740..643467 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag PS040_RS03190 Protein ID WP_000550189.1
Coordinates 642740..643054 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS040_RS03195 Protein ID WP_000560272.1
Coordinates 643051..643467 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS03170 (638899) 638899..639885 - 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -
PS040_RS03175 (639964) 639964..640656 - 693 WP_000942533.1 vancomycin high temperature exclusion protein -
PS040_RS03180 (640733) 640733..641236 - 504 WP_273782896.1 M48 family metallopeptidase -
PS040_RS03185 (641321) 641321..642457 + 1137 WP_273782898.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
PS040_RS03190 (642740) 642740..643054 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
PS040_RS03195 (643051) 643051..643467 + 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
PS040_RS03200 (643557) 643557..645575 - 2019 WP_273782900.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PS040_RS03205 (645917) 645917..648268 - 2352 WP_000695424.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T271792 WP_000550189.1 NZ_CP117637:642740-643054 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT271792 WP_000560272.1 NZ_CP117637:643051-643467 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References