Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 601154..601953 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag PS040_RS02985 Protein ID WP_059271009.1
Coordinates 601154..601618 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS040_RS02990 Protein ID WP_001296435.1
Coordinates 601618..601953 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS02955 (596155) 596155..596589 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PS040_RS02960 (596607) 596607..597485 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS040_RS02965 (597475) 597475..598254 - 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS040_RS02970 (598265) 598265..598738 - 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS040_RS02975 (598761) 598761..600041 - 1281 WP_273782873.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS040_RS02980 (600290) 600290..601099 + 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
PS040_RS02985 (601154) 601154..601618 - 465 WP_059271009.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS040_RS02990 (601618) 601618..601953 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS040_RS02995 (602102) 602102..603673 - 1572 WP_256879795.1 galactarate dehydratase -
PS040_RS03000 (604044) 604044..605378 + 1335 WP_273782877.1 galactarate/glucarate/glycerate transporter GarP -
PS040_RS03005 (605394) 605394..606164 + 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17835.26 Da        Isoelectric Point: 9.6804

>T271791 WP_059271009.1 NZ_CP117637:c601618-601154 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271791 WP_001296435.1 NZ_CP117637:c601953-601618 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References