Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 233677..234389 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS040_RS01055 Protein ID WP_000162413.1
Coordinates 234087..234389 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS040_RS01050 Protein ID WP_000806446.1
Coordinates 233677..234015 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS01025 (228732) 228732..230714 + 1983 WP_107193138.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS040_RS01030 (230763) 230763..231791 + 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
PS040_RS01035 (231863) 231863..232393 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS040_RS01040 (232540) 232540..233106 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS040_RS01045 (233453) 233453..233620 - 168 WP_273782721.1 hypothetical protein -
PS040_RS01050 (233677) 233677..234015 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS040_RS01055 (234087) 234087..234389 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS040_RS01060 (234553) 234553..235032 + 480 WP_273782723.1 hypothetical protein -
PS040_RS01065 (235122) 235122..235295 - 174 WP_000553433.1 hypothetical protein -
PS040_RS01070 (235323) 235323..235406 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS040_RS01075 (235460) 235460..236812 - 1353 WP_273782725.1 glutathione-disulfide reductase -
PS040_RS01080 (236884) 236884..237726 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271789 WP_000162413.1 NZ_CP117637:c234389-234087 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271789 WP_000806446.1 NZ_CP117637:c234015-233677 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References