Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4403238..4403950 Replicon chromosome
Accession NZ_CP117628
Organism Escherichia albertii strain BIA_22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PS041_RS22055 Protein ID WP_149507580.1
Coordinates 4403238..4403540 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS041_RS22060 Protein ID WP_000806446.1
Coordinates 4403612..4403950 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS041_RS22035 (4399873) 4399873..4400715 + 843 WP_001296497.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
PS041_RS22040 (4400787) 4400787..4402139 + 1353 WP_149452210.1 glutathione-disulfide reductase -
PS041_RS22045 (4402193) 4402193..4402276 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS041_RS22050 (4402567) 4402567..4403046 - 480 WP_273824558.1 hypothetical protein -
PS041_RS22055 (4403238) 4403238..4403540 + 303 WP_149507580.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS041_RS22060 (4403612) 4403612..4403950 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
PS041_RS22065 (4404007) 4404007..4404186 + 180 WP_002460167.1 hypothetical protein -
PS041_RS22070 (4404533) 4404533..4405099 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS041_RS22075 (4405246) 4405246..4405776 + 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS041_RS22080 (4405848) 4405848..4406876 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS041_RS22085 (4406925) 4406925..4408906 - 1982 Protein_4310 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11901.61 Da        Isoelectric Point: 9.8664

>T271774 WP_149507580.1 NZ_CP117628:4403238-4403540 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPSNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT271774 WP_000806446.1 NZ_CP117628:4403612-4403950 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References